| Item Type | Name |
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Concept
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Cell Adhesion Molecules
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Concept
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Intercellular Signaling Peptides and Proteins
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Concept
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Shc Signaling Adaptor Proteins
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Concept
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Adaptor Proteins, Signal Transducing
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Concept
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MAP Kinase Signaling System
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Concept
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Intracellular Signaling Peptides and Proteins
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Concept
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Signal Transduction
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Academic Article
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p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl.
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Academic Article
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Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line.
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Academic Article
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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL).
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Academic Article
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Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL.
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Academic Article
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p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.
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Academic Article
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The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells.
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Academic Article
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The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors.
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Academic Article
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Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.
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Academic Article
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The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.
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Academic Article
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The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins.
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Academic Article
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Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.
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Academic Article
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Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells.
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Academic Article
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Hematopoietic growth factors signal through the formation of reactive oxygen species.
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Academic Article
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Role of focal adhesion proteins in signal transduction and oncogenesis.
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Academic Article
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Thrombopoietin induces activation of the phosphatidylinositol-3' kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL.
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Academic Article
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The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase.
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Academic Article
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The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.
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Academic Article
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The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells.
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Academic Article
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Molecular abnormalities in lung cancer.
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Academic Article
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Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.
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Academic Article
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Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
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Academic Article
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A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.
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Academic Article
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Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.
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Academic Article
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SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL.
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Academic Article
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Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells.
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Academic Article
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CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.
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Academic Article
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Role of the cytoskeletal protein paxillin in oncogenesis.
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Academic Article
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Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.
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Academic Article
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Role of receptor tyrosine kinases in lung cancer.
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Academic Article
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Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer.
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Academic Article
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c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions.
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Academic Article
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Fibronectin enhances viability and alters cytoskeletal functions (with effects on the phosphatidylinositol 3-kinase pathway) in small cell lung cancer.
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Academic Article
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Targeted molecules in small cell lung cancer.
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Academic Article
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Targeting c-Kit mutations: basic science to novel therapies.
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Academic Article
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A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.
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Academic Article
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Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer.
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Academic Article
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Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.
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Academic Article
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Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2.
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Academic Article
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Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells.
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Academic Article
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Molecular biology of malignant mesothelioma: a review.
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Academic Article
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Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomas.
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Academic Article
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c-Met: structure, functions and potential for therapeutic inhibition.
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Academic Article
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Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
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Academic Article
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The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.
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Academic Article
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The role of ephrins and Eph receptors in cancer.
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Academic Article
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MET pathway as a therapeutic target.
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Academic Article
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EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation.
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Academic Article
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Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma.
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Academic Article
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MET receptor tyrosine kinase.
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Academic Article
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The role of chemokine receptor CXCR4 in lung cancer.
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Academic Article
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Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin.
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Academic Article
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Fyn is downstream of the HGF/MET signaling axis and affects cellular shape and tropism in PC3 cells.
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Academic Article
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Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion.
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Academic Article
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Non-receptor tyrosine kinase inhibitors in lung cancer.
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Academic Article
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Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways.
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Academic Article
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A novel classification of lung cancer into molecular subtypes.
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Academic Article
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Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.
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Academic Article
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Melanoma proteoglycan modifies gene expression to stimulate tumor cell motility, growth, and epithelial-to-mesenchymal transition.
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Academic Article
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CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells.
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Academic Article
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Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.
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Academic Article
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The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
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Academic Article
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Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
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Academic Article
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Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer.
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Academic Article
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Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma.
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Academic Article
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Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1).
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Academic Article
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Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells.
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Academic Article
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Involvement of the adapter protein CRKL in integrin-mediated adhesion.
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Academic Article
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Inhibition of epidermal growth factor receptor signaling in malignant pleural mesothelioma.
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Academic Article
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Molecular and cellular biology of small cell lung cancer.
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Academic Article
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Key signaling pathways and targets in lung cancer therapy.
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Academic Article
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Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.
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Academic Article
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Novel targets for therapeutic agents in small cell lung cancer.
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Academic Article
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RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.
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Academic Article
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Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence.
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Academic Article
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Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.
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Academic Article
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The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target.
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Academic Article
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The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer.
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Academic Article
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Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells.
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Academic Article
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Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides.
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Academic Article
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Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer.
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Academic Article
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Molecular pathways and therapeutic targets in lung cancer.
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Academic Article
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Fibroblast growth factor signaling and inhibition in non-small cell lung cancer and their role in squamous cell tumors.
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Academic Article
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Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
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Academic Article
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Nuclear epidermal growth factor receptor is a functional molecular target in triple-negative breast cancer.
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Academic Article
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Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung Cancer.
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Academic Article
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Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
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Academic Article
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FAK and paxillin, two potential targets in pancreatic cancer.
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Academic Article
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Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.
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Academic Article
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PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma.
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Academic Article
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RETRACTED: The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor.
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Academic Article
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MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale.
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Academic Article
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Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma.
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Academic Article
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2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer.
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Academic Article
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EphB4: A promising target for upper aerodigestive malignancies.
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Academic Article
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2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76.
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Academic Article
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Inhibiting crosstalk between MET signaling and mitochondrial dynamics and morphology: a novel therapeutic approach for lung cancer and mesothelioma.
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Academic Article
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Notch signaling in breast cancer: From pathway analysis to therapy.
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Academic Article
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer.
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Academic Article
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RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis.
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Academic Article
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Therapeutic targeting of miRNA-216b in cancer.
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Academic Article
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AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer.
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Academic Article
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MET receptor in oncology: From biomarker to therapeutic target.
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Academic Article
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Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas.
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Academic Article
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Activating p53 function by targeting RLIP.
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Academic Article
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The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC).
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Academic Article
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RLIP depletion induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.
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Academic Article
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Retraction.
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Academic Article
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Correction: 2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer.
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Academic Article
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RLIP: A necessary transporter protein for translating oxidative stress into pro-obesity and pro-carcinogenic signaling.
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Grant
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Role of Paxillin in Lung Cancer
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Grant
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Role of c-Met in SCLC and Potential for Novel Therapy
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Grant
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Novel Targeted Therapy in Pancreatic Cancer
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Grant
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Studies of a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
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Grant
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PAXILLIN--AN ONCOGENE ACTIVATED PROTEIN
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Academic Article
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The innate effects of plant secondary metabolites in preclusion of gynecologic cancers: Inflammatory response and therapeutic action.
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Academic Article
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Regression of ovarian cancer xenografts by depleting or inhibiting RLIP.
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